CMKLR1 antibody

Catalog No. ABIN5541107

This Mouse Monoclonal antibody specifically detects CMKLR1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CMKLR1 antibody (ABIN5541107)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CMKLR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1A7

Product Details anti-CMKLR1 Antibody

Specificity: This antbody detects Chemerin receptor.

Purification: Affinity Chromatography on Protein G

Immunogen: DNA vaccine

Isotype: IgG2b

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 1 μg/mL (1/200) predigestion w ith proteinase K required.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Alternative Name: chemokine receptor-like 1

Background: G - protein coupled receptor ChemR23 is a 373 amino acid protein that belongs to the G - protein coupled receptor 1 family, with two potential glycosylation sites and one disulfide bond. The ligand Chemerin (or retinoic acid receptor responder protein 2 , RARRES2) is a 14 kDa protein found to stimulate chemotaxis of dendritic cells , monocytes / macrophages and natural killer cells to the site of inflammation. Accordingly, there is abundant expression of the receptor on these cells. ChemR23 is prominently expressed in developing osseous and cartilaginous tissue, as well as in tissues associated with hematopoietic and immune function including spleen, thymus, appendix, lymph node, bone marrow and fetal liver. The rece ptor is also found in adult parathyroid glands, in the cardiovascular system, brain, kidney, gastrointestinal and myeloid tissues and on endothelial cells. ChemR23 a cts as a cor eceptor for several SIV strains, as well as a primary HIV - 1 strain.

UniProt: Q99788